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Chemical Structure : AM4113
CAS No.: 614726-85-1
Catalog No.: PC-21521Not For Human Use, Lab Use Only.
AM4113 is a high affinity, selective cannabinoid CB1 neutral antagonist with Ki of 0.89 nM, exhibits 100-fold selectivity over CB2 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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AM4113 is a high affinity, selective cannabinoid CB1 neutral antagonist with Ki of 0.89 nM, exhibits 100-fold selectivity over CB2 receptors.
AM4113 does not change the forskolin-stimulated cAMP accumulation in CB1-transfected HEK cells up to concentrations of 10 µM.
AM4113 attenuated the AM411-induced locomotor suppression (p<0.01 at 2 mg/ kg; p<0.05 at 4 mg/kg) and analgesia.
AM4113 (4.0 mg/kg) alone significantly suppressed locomotor activity compared to vehicle.
AM4113 suppressed food-reinforced operant responding with rats responding on fixed ratio (FR) 1 and 5 schedules of reinforcement in a dose-dependent manner, and also suppressed feeding on high-fat, high-carbohydrate, and lab chow diets.
| M.Wt | 380.65 | |
| Formula | C17H12Cl3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide |
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1. Sink KS, et al. Neuropsychopharmacology. 2008 Mar;33(4):946-55.
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