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Chemical Structure : AM6527
Catalog No.: PC-21463Not For Human Use, Lab Use Only.
AM6527 is a highly potent, selective cannabinoid CB1 receptor antagonist with binding Ki of 4.88 nM, 100-fold selective over CB2 receptors.
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AM6527 is a highly potent, selective cannabinoid CB1 receptor antagonist with binding Ki of 4.88 nM, 100-fold selective over CB2 receptors.
AM6527 shows no affinity against a variety of neurotransmitter related receptors, ion-channels, enzymes and peptides.
AM6527 produced a dose-dependent decrease in responding on FR5 in rates with ED50 of 1.49 mg/kg (orally administered).
| M.Wt | 374.46 | |
| Formula | C24H23FN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Limebeer CL, et al. Br J Pharmacol. 2010 Sep;161(2):336-49.
2. Sink KS, et al. Pharmacol Biochem Behav. 2009 Jan;91(3):303-6.
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