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Chemical Structure : AMD-070 hydrochloride
CAS No.: 880549-30-4
Catalog No.: PC-45824Not For Human Use, Lab Use Only.
AMD-070 (Mavorixafor) hydrochloride is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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AMD-070 (Mavorixafor) hydrochloride is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.
AMD-070 displays no significant activity (IC50>10 uM) for a series of other closely GPCRs (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2).
AMD-070 inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 of 2 nM and 26 nM, respectively, with noncytotoxic to cells (>23 uM).
AMD-070 exhibits good PK profiles and excellent oral bioavailability.
AMD-070 also inhibits CXCR4/SDF-1-mediated events in ALL cancer cells and transplant models.
| M.Wt | 458.8554 | |
| Formula | C21H30Cl3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,4-Butanediamine, N1-(1H-benzimidazol-2-ylmethyl)-N1-[(8S)-5,6,7,8-tetrahydro-8-quinolinyl]-, hydrochloride (1:1) |
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1. Skerlj RT, et al. J Med Chem. 2010 Apr 22;53(8):3376-88.
2. Stone ND, et al. Antimicrob Agents Chemother. 2007 Jul;51(7):2351-8.
3. Parameswaran R, et al. Leukemia. 2011 Aug;25(8):1314-23.
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