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Chemical Structure : AMG-1694
Catalog No.: PC-63223Not For Human Use, Lab Use Only.
AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly.
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AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly; exhibits robust glucose lowering in diabetic mouse models, AMG-3969 is highly effective in promoting carbohydrate substrate use, demonstrates a robust pharmacodynamic response (GK translocation, mGKGK translocation EC50=0.2 uM) as well as statistically significant dose-dependent reductions in fed blood glucose levels.
| M.Wt | 533.625 | |
| Formula | C23H30F3N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lloyd DJ, et al. Nature. 2013 Dec 19;504(7480):437-40.
2. Ashton KS, et al. J Med Chem. 2014 Jan 23;57(2):309-24.
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