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Chemical Structure : AMG-208
CAS No.: 1002304-34-8
Catalog No.: PC-42849Not For Human Use, Lab Use Only.
AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM.
AMG-208 inhibits HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM.
AMG-208 suppresses proliferation and induces apoptosis in human tumor xenograft models.
| M.Wt | 383.4027 | |
| Formula | C22H17N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 1 mg/mL |
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| Chemical Name/SMILES |
Quinoline, 7-methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]- |
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1. Hong DS, et al. Oncotarget. 2015 Jul 30;6(21):18693-706.
2. Albrecht BK, et al. J Med Chem. 2008 May 22;51(10):2879-82.
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