Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AMG-337
CAS No.: 1173699-31-4
Catalog No.: PC-45530Not For Human Use, Lab Use Only.
AMG-337 is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AMG-337 is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM.
AMG-337 inhibits of HGF-mediated MET phosphorylation in PC3 cells.
AMG-337 shows desirable preclinical pharmacokinetics, significant inhibition of MET phosphorylation in mice, and robust tumor growth inhibition in a MET-dependent mouse efficacy model.
| M.Wt | 463.4643 | |
| Formula | C23H22FN7O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 30 mg/mL |
|
| Chemical Name/SMILES |
1,6-Naphthyridin-5(6H)-one, 6-[(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)- |
|
1. Boezio AA, et al. J Med Chem. 2016 Mar 24;59(6):2328-42.
2. Hughes PE, et al. Mol Cancer Ther. 2016 Jul;15(7):1568-79.
3. Du Z, et al. Mol Cancer Ther. 2016 Jun;15(6):1227-37.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
