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Chemical Structure : AMG-548
Catalog No.: PC-62439Not For Human Use, Lab Use Only.
AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ.
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AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chronic models of arthritis.
Rheumatoid Arthritis
Discontinued
| M.Wt | 461.569 | |
| Formula | C29H27N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.
2. Lee MR, et al. Curr Med Chem. 2005;12(25):2979-94.
3. Dominguez C, et al. Curr Opin Drug Discov Devel. 2005 Jul;8(4):421-30.
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