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Chemical Structure : AMG21629
Catalog No.: PC-49443Not For Human Use, Lab Use Only.
AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively.
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AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively.
AMG21629 displayss >4000-fold selectivity for TRPV1 over other TRP channels.
AMG21629 blocks capsaicin-induced flinch response and causes hyperthermia in rats.
| M.Wt | 472.428 | |
| Formula | C22H19F3N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nuria Tamayo, et al. J Med Chem. 2008 May 8;51(9):2744-57.
2. Matthew I Brier, et al. Sci Rep. 2020 Aug 4;10(1):13096.
3. Narender R Gavva, et al. J Neurosci. 2007 Mar 28;27(13):3366-74.
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