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Chemical Structure : AMG2504
Catalog No.: PC-49701Not For Human Use, Lab Use Only.
AMG2504 (AMG 2504) is a selective small molecule TRPA1 inhibitor, inhibits AITC-induced increase in intracellular calcium mediated by TRPA1 in CHO cells with IC50 of 35 nM.
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AMG2504 (AMG 2504) is a selective small molecule TRPA1 inhibitor, inhibits AITC-induced increase in intracellular calcium mediated by TRPA1 in CHO cells with IC50 of 35 nM.
AMG2504 displays no activity against hTRPV1, hTRPM8, hTRPV3 and hTRPV4 at 5 uM.
AMG2504 marginally inhibited rat TRPA1 activation by AITC.
| M.Wt | 440.12 | |
| Formula | C15H10Cl4N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lana Klionsky, et al. Mol Pain. 2007 Dec 17;3:39. doi: 10.1186/1744-8069-3-39.
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