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Chemical Structure : AMG511
CAS No.: 253573-53-3
Catalog No.: PC-60983Not For Human Use, Lab Use Only.
AMG511 (AMG-511) potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AMG511 (AMG-511) potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively.
AMG511 displays high selectivity over other members of the closely related PIKK family of kinases, including mTOR, hVPS34 and PI4Ks, as well as a panel of 370 protein kinases (IC50>1 uM).
AMG511 inhibits AKT (Ser473) phosphorylation in U87 MG glioblastoma cells with IC50 of 4 nM.
AMG511 potently blocks the targeted PI3K pathway in mouse liver pharmacodynamic model and inhibits tumor growth in U87 malignant glioma glioblastoma xenograft model.
| M.Wt | 517.584 | |
| Formula | C22H28FN9O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4- (methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine |
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1. Norman MH, et al. J Med Chem. 2012 Sep 13;55(17):7796-816.
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