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Chemical Structure : AMTB hydrochloride
Catalog No.: PC-60718Not For Human Use, Lab Use Only.
A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6).
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A selective TRPM8 channel blocker with pEC50 of 6.91 in Ca(2+) influx assay, with no activity for TRPV4 (pEC50<4.6); inhibits icilin-activated Ca2 influx in HEK293 cells with pIC50 of 6.23, decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction in anesthetized rats; also reduces proliferation rates and proliferative fraction in prostate cancer cells, but not of non-tumor prostate cells.
| M.Wt | 430.99 | |
| Formula | C23H26N2O2S.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lashinger ES, et al. Am J Physiol Renal Physiol. 2008 Sep;295(3):F803-10.
2. Valero ML, et al. PLoS One. 2012;7(12):e51825.
3. Uvin P, et al. Eur Urol. 2015 Oct;68(4):655-61.
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