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AN-12-H5

Chemical Structure : AN-12-H5

CAS No.: 1193340-31-6

AN-12-H5

Catalog No.: PC-62927Not For Human Use, Lab Use Only.

AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM; mutations in capsid proteins (G3112A, VP1-Ala224Thr, and G2396A, VP3-Arg227Lys mutations) are resistant to AN-12-H5.

Physicochemical Properties

M.Wt 513.645
Formula C24H23N3O4S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((6aS,8S)-2-(4-(methylthio)phenyl)-6,12-dioxo-5,6,6a,7,8,9,10,12-octahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-8-yl)thiophene-2-sulfonamide

References

1. Arita M, et al. J Gen Virol. 2010 Nov;91(Pt 11):2734-44.

2. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

3. Arita M, et al. J Virol. 2013 Apr;87(8):4252-60.

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