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Chemical Structure : ANA-0
Catalog No.: PC-49476Not For Human Use, Lab Use Only.
ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity.
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ANA-0 is a potent inhibitor against the replication of multiple subtypes of influenza A virus, interacts with N-terminal domain of the PA subunit with Kd value of 1.1 uM, and impedes it's endonuclease activity.
ANA-0 showed cross-subtype protection against influenza A virus infections in vitro and in vivo.
ANA-0 (20 uM) exhibited antiviral effects against infections of H3N2, H5N1, H7N7, H7N9 and H9N2 viruses in cell cultures.
ANA-0 showed IC50 of 2.5 uM against H5N1 and H7N7 viruses.
ANA-0 (2 mg/kg/day, intranasal treatment) inhibited virus growth in mice challenged with LD80 of mouse-adapted H1N1 virus, inhibited the viral transcription.
ANA-0 demonstrated synergistic antiviral effect when combined with zanamivir.
| M.Wt | 389.389 | |
| Formula | C19H11N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shuofeng Yuan, et al. Sci Rep. 2016 Mar 9;6:22880.
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