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ANT431

Chemical Structure : ANT431

CAS No.: 1639972-90-9

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ANT431 (ANT 431, ANT-431)

Catalog No.: PC-63324Not For Human Use, Lab Use Only.

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively).
    ANT431 potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE.
    ANT431 restore meropenem (MEM) efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.

    Physicochemical Properties

    M.Wt 285.292
    Formula C9H7N3O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(pyridine-3-sulfonamido)thiazole-4-carboxylic acid

    References

    1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.

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