Chemical Structure : AP232
CAS No.:
AP232
(AP-232)
Catalog No.: PC-25819Not For Human Use, Lab Use Only.
AP232 is a specific small molecule splicing factor U2AF-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AP232 is a specific small molecule splicing factor U2AF-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
AP232 has 31-fold improvement in the IC50 value than SF153 (Cat# PC-25479) against U2AF1-UHM based on the HTRF assay.
AP232 potently inhibits growth in HNT-34 (IC50 = 6.49 ± 0.38 μM) and MONO-MAC-1 (IC50 = 14.09 uM).
AP232 (20 uM) 2markedly increased the G2/M population in NKM-1 cells at 48 h.
AP232 impares lysosome acidification and autophagy in leukemia cells.
Physicochemical Properties
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M.Wt
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329.49
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Formula
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C20H31N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-(4-ethoxy-1H-indol-3-yl)butan-2-yl)-4-methylpiperidin-4-amine
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References
1. Patil AD, et al. ACS Med Chem Lett. 2025 Sep 11;16(10):2015-2021.
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