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Chemical Structure : APD597
CAS No.: 897732-93-3
Catalog No.: PC-20429Not For Human Use, Lab Use Only.
APD597 (JNJ-38431055) is a potent, selective GPR119 agonist with EC50 of 46 nM and 421 nM for human and rat GPR119, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | $728 | In stock | |
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APD597 (JNJ-38431055) is a potent, selective GPR119 agonist with EC50 of 46 nM and 421 nM for human and rat GPR119, respectively.
APD597 showed no significant activity in a standard CEREP receptor selectivity panel at 1 uM.
APD597 (3-30 mg/kg PO) improved glucose handling and markedly reduced the AUCglu in an oGTT in male C57bl/6j mice.
| M.Wt | 479.55 | |
| Formula | C21H29N5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
isopropyl 4-((5-methoxy-6-((2-methyl-6-(methylsulfonyl)pyridin-3-yl)amino)pyrimidin-4-yl)oxy)piperidine-1-carboxylate |
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1. Semple G, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-5.
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