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Chemical Structure : APS-2-79
CAS No.: 2002381-25-9
Catalog No.: PC-42215Not For Human Use, Lab Use Only.
APS-2-79 is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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APS-2-79 is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM).
APS-2-79 binds to the KSR2-MEK1 complex and impedes the assembly of RAF–KSR–MEK complexes, suppresses KSR-stimulated MEK and ERK phosphorylation and suppresses oncogenic Ras mutations.
APS-2-79 enhances the efficacy of Trametinib against cancer cell lines containing K-Ras mutations.
| M.Wt | 387.4312 | |
| Formula | C23H21N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)- |
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1. Dhawan NS, et al. Nature. 2016 Sep 1;537(7618):112-116.
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