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Chemical Structure : APX2009
Catalog No.: PC-60633Not For Human Use, Lab Use Only.
APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition.
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APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition.
APX2009 inhibits endothelial cell proliferation in HRECs and Rf/6a cells in vitro with GI50 of 1.1 and 26 uM, respectively.
APX2009 significantly inhibits endothelial tube formation in HRECs and Rf/6a cells in vitro, inhibits TNF-α mediated NF-κB signaling and proangiogenic target gene mRNA expression.
APX2009 inhibits choroidal sprouting at low micromolar in ex vivo, blocks ocular angiogenesis in vitro and ex vivo.
| M.Wt | 355.43 | |
| Formula | C21H25NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kelley MR, et al. J Pharmacol Exp Ther. 2016 Nov;359(2):300-309.
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