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Chemical Structure : AR-A014418
CAS No.: 487021-52-3
Catalog No.: PC-42628Not For Human Use, Lab Use Only.
AR-A014418 is a potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AR-A014418 is a potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM.
AR-A014418 shows no significantly inhibition on CDK2, CDK5 (IC50>100 uM) or 26 other kinases.
AR-A014418 inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in cells and protects N2A neuroblastoma cells against cell death mediated by inhibition of PI3K/Akt pathway.
| M.Wt | 308.3131 | |
| Formula | C12H12N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-[(4-methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)- |
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1. Bhat R, et al. J Biol Chem. 2003 Nov 14;278(46):45937-45.
2. Martins DF, et al. J Pain. 2011 Mar;12(3):315-22.
3. Mazzardo-Martins L, et al. Neuroscience. 2012 Dec 13;226:411-20.
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