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Chemical Structure : ARN-3236
CAS No.: 1613710-01-2
Catalog No.: PC-61766Not For Human Use, Lab Use Only.
ARN-3236 (ARN3236) is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ARN-3236 (ARN3236) is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM.
ARN-3236 does not significantly inhibit SIK1 and SIK3, as well as other AMPK family members.
ARN-3236 inhibits the growth of 10 ovarian cancer cell lines with IC50 of 0.8-2.6 uM.
ARN-3236 increasess centrosome uncoupling from nucleus, and inhibits centrosome splitting in mitotic cells.
ARN-3236 induces cell cycle arrest, apoptosis and tetraploidy, also inhibits AKT phosphorylation and attenuates survivin expression.
ARN-3236 sensitizes ovarian cancer to paclitaxel in SKOv3ip xenograft model.
| M.Wt | 336.409 | |
| Formula | C19H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine |
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1. Zhou J, et al. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954.
2. Bon H, et al. Mol Cancer Res. 2015 Apr;13(4):620-635.
3. Lombardi MS, et al. J Leukoc Biol. 2016 May;99(5):711-21.
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