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Chemical Structure : ARN-5187
Catalog No.: PC-61357Not For Human Use, Lab Use Only.
ARN-5187 (ARN5187) is a lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.
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ARN-5187 (ARN5187) is a lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.
ARN-5187 relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells.
ARN-5187 disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability.
ARN-5187 a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine.
| M.Wt | 397.538 | |
| Formula | C24H32FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. De Mei C, et al. Oncogene. 2015 May 14;34(20):2597-608.
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