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ARN-75039

Chemical Structure : ARN-75039

CAS No.: 2436472-47-6

ARN-75039 (ARN75039)

Catalog No.: PC-72615Not For Human Use, Lab Use Only.

ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ARN-75039 (ARN75039) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 0.13 and 4.3 nM, respectively.
ARN-75039 demonstrated sub-nanomolar EC50 activity against pTCRV that further translated to native wild-and NWAs, including LASV, JUNV and MACV, in pseudotyped virus assays and against native replicative LASV and JUNV.
ARN-75039 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.
ARN-75039 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection.

Physicochemical Properties

M.Wt 414.549
Formula C27H30N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-(tert-butoxy)phenyl)-6-(4-isopropoxyphenyl)-7-methylimidazo[1,2-a]pyridine

References

1. Brian B Gowen, et al. Antiviral Res. 2021 Sep;193:105125.

2. Michael B Plewe, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127983.

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