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Chemical Structure : ARRY-371797
CAS No.: 1036404-17-7
Catalog No.: PC-72610Not For Human Use, Lab Use Only.
ARRY-371797 (ARRY371797) is a potent, selective, oral p38α inhibitor with IC50 of <5 nM, directly inhibits LPS-induced IL-6 production from RPMI-8226 with IC50 of 0.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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ARRY-371797 (ARRY371797) is a potent, selective, oral p38α inhibitor with IC50 of <5 nM, directly inhibits LPS-induced IL-6 production from RPMI-8226 with IC50 of 0.1 nM.
ARRY-797 (30 mg/kg, oral) inhibits LPS induced IL-6 and TNF-alpha in SCID-beige mice; inhibited LPS-induced phosphorylation of p38 in RPMI-8226 xenografts.
ARRY-797 is the first small molecule p38 inhibitor to demonstrate single agent activity in a MM xenograft model.
| M.Wt | 416.473 | |
| Formula | C22H26F2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)-1-isobutyl-1H -indazole-6-carboxamide |
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1. Dale Wright, PhD, et al. Blood (2006) 108 (11): 3478.
2. Muchir A, et al. Hum Mol Genet. 2012 Oct 1;21(19):4325-33.
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