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Chemical Structure : ARS-853
CAS No.: 1629268-00-3
Catalog No.: PC-45673Not For Human Use, Lab Use Only.
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM.
ARS-853 engages KRASG12C in biochemical assay with a rate constant of 76 M-1s-1, > 600-fold improvement compared with Compound 12 (Ostrem JM, Nature 2013;503:548–51.).
ARS-853 inhibits growth of H358 cells.
ARS-853 is the first direct KRAS inhibitor shown to selectively inhibit KRAS in cells with potency in the range of a drug candidate.
| M.Wt | 432.9437 | |
| Formula | C22H29ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 71 mg/mL |
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| Chemical Name/SMILES |
2-Propen-1-one, 1-[3-[4-[2-[[4-chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]- |
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1. Patricelli MP, et al. Cancer Discov. 2016 Mar;6(3):316-29.
2. Lito P, et al. Science. 2016 Feb 5;351(6273):604-8.
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