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Chemical Structure : ART26.12
Catalog No.: PC-21691Not For Human Use, Lab Use Only.
ART26.12 is a third generation, selective fatty acid-binding protein 5 (FABP5) inhibitor with Ki value of 0.77 uM, >25-fold selective over FABP3, FABP4 and FABP7.
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ART26.12 is a third generation, selective fatty acid-binding protein 5 (FABP5) inhibitor with Ki value of 0.77 uM, >25-fold selective over FABP3, FABP4 and FABP7.
ART26.12 is effective at treating and preventing oxaliplatin-induced neuropathy.
Coadministration of ART26.12 (10 and 25 mg/kg BID for 15 days) with oxaliplatin prevented thermal hyperalgesia, mitigated mechanical allodynia, and attenuated OXA-induced weight loss in oxaliplatin-induced peripheral neuropathy (OIPN) model.
| M.Wt | 472.54 | |
| Formula | C29H28O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. W G Warren, et al. J Pain. 2024 Jan 15:S1526-5900(24)00345-6.
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