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Chemical Structure : AS-0141
CAS No.: 1402057-88-8
Catalog No.: PC-72755Not For Human Use, Lab Use Only.
Monzosertib (AS 0141) is a potent, selective, orally bioavailable CDC7 inhibitor with IC50 of 2.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Monzosertib (AS 0141) is a potent, selective, orally bioavailable CDC7 inhibitor with IC50 of 2.4 nM.
AS-0141 demonstrated excellent kinase selectivity and favorable oral bioavailability in multiple species, and robust in vivo antitumor efficacy in a colorectal cancer xenograft model.
| M.Wt | 465.433 | |
| Formula | C21H22F3N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ethyl (E)-5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-4-oxo-2-((4-(2,2,2-trifluoroethyl)piperazin-1-yl)amino)-4,5-dihydrofuran-3-carboxylate |
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1. Takayuki Irie, et al. J. Med. Chem. 2021, 64, 19, 14153–14164.
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