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Chemical Structure : AS1928370
Catalog No.: PC-35235Not For Human Use, Lab Use Only.
AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM.
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AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM.
AS1928370 (ASP8370) demonstrates high aqueous solubility (pH6.8, >100 uM), satisfactory stability in human liver microsomes, and reduced CYP3A4 inhibition.
AS1928370 (ASP8370) improves capsaicin-induced secondary hyperalgesia and mechanical allodynia in an L5/L6 spinal nerve ligation model in rats with respective ED50s of 0.17 and 0.26 mg/kg p.o.
| M.Wt | 453.586 | |
| Formula | C29H31N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Oka H, et al. Bioorg Med Chem. 2018 Jul 23;26(12):3716-3726.
2. Watabiki T, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):743-50.
3. Watabiki T, et al. Biol Pharm Bull. 2011;34(7):1105-8.
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