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Chemical Structure : AS2541019
Catalog No.: PC-63185Not For Human Use, Lab Use Only.
AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms.
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AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms.
AS2541019 inhibits Akt phosphorylation in human Ramos B cell line with IC50 of 14.3 nM.
AS2541019 effectively inhibits anti-IgM stimulated B cell proliferation and human B cell proliferation with IC50 of 4.3 and 3.6 nM, respectively.
AS2541019 significantly inhibits both T-dependent and T-independent de novo antibody production in peripheral blood in vivo.
AS2541019 significantly prolongs graft survival time by inhibiting xenoreactive antibody production in rat concordant xenotransplant model.
| M.Wt | 529.593 | |
| Formula | C26H33F2N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marui T, et al. Eur J Pharmacol. 2018 Mar 5. pii: S0014-2999(18)30133-X.
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