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Chemical Structure : AS2676293
Catalog No.: PC-21026Not For Human Use, Lab Use Only.
AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
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AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM.
AS2676293 (0.3-3 mg/kg, oral) inhibited bone loss significantly in RANKL-induced osteopenic mice.
AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.
AS2676293 suppressed RANKL-mediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10, which is known not to trigger osteoclast activation.
| M.Wt | 378.33 | |
| Formula | C18H14F4N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Junji Miyata, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5681-4.
2. Vagelis Rinotas, et al. Int J Mol Sci. 2023 Jul 10;24(14):11290.
3. Nakai Y, et al. Bone Res. 2019 Jan 3;7:1. doi: 10.1038/s41413-018-0036-5.
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