Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AS2677131
CAS No.: 2171502-44-4
Catalog No.: PC-60991Not For Human Use, Lab Use Only.
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM); inhibits the production of IL-12p40, IL-6 and IL-1β but not TNFα in activated macrophages or dendritic cells, and expression of IgM-induced MHC class II on B cells; reduces Akt phosphorylation in IFNγ/LPS-stimulated RAW264.7 cells, greatly increases cell size with many small vesicles in the cytoplasm.
| M.Wt | 470.577 | |
| Formula | C27H30N6O2 | |
| CAS No. | 2171502-44-4 | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name |
rel-N-{6'-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3,3'-bipyridin-5-yl}-3-ethyl-2-methyl-1H-pyrrolo[3,2-b]pyridine-5-carboxamide |
|
1. Terajima M, et al. Eur J Pharmacol. 2016 Jun 5;780:93-105.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
