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Chemical Structure : AS703026
CAS No.: 1236699-92-5
Catalog No.: PC-42857Not For Human Use, Lab Use Only.
AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 100 mg | $248 | In stock | |
| 200 mg | $388 | In stock | |
| 1 g | $388 | In stock |
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AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.
AS703026 (Pimasertib) has IC50 of 10 nM against INA-6 cells, approximately 10-fold more potent than AZD6244 at inhibiting cytokine-induced osteoclast differentiation in vitro.
AS703026 (Pimasertib) effectively inhibits the growth of D-MUT cells in vitro and in vivo by specific inhibition of the key MEK downstream target kinase ERK.
AS703026 (Pimasertib) also enhances gemcitabine efficacy in pancreatic cancer models by reducing ribonucleotide reductase subunit-1 (RRM1).
| M.Wt | 431.2008 | |
| Formula | C15H15FIN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Pyridinecarboxamide, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]- |
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1. Kim K, et al. Br J Haematol. 2010 May;149(4):537-49.
2. Yoon J, et al. Cancer Res. 2011 Jan 15;71(2):445-53.
3. Park SJ, et al. Am J Med Sci. 2013 Dec;346(6):494-8.
4. Vena F, et al. Clin Cancer Res. 2015 Dec 15;21(24):5563-77.
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