Catalog No.: PC-22165Not For Human Use, Lab Use Only.
ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively.
ASP1617 (ASP-1617) is a potent, highly specific and orally active cathepsin S (CatS) inhibitor with IC50 of 4.6 nM and 0.39 nM for human and mouse CatS, respectively.
ASP1617 does not show significant activity for CatB, CatV, matriptase 2, and papain activities on a panel 61 different proteases.
ASP1617 induced invariant chain accumulation and decreased the expression level of MHC class ΙΙ on the cell surface in both mouse and human B cells.
ASP1617 prevented DO11.10 mice T cell proliferation to ovalbumin antigen.
Oral administration of ASP1617 suppressed anti-dsDNA IgG, prevented progression of lupus-like glomerulonephritis, and significantly prevented proteinuria excretion in SLE mouse model.
