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Chemical Structure : ASP6432
Catalog No.: PC-35197Not For Human Use, Lab Use Only.
ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.
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ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.
ASP6432 also inhibits the LPA-induced [Ca2+]i increase in cells expressing rat LPA1 (IC50=30 nM), weakly inhibits LPA-induced [Ca2+]i increase in cells expressing human LPA4 (IC50=114 nM), and shows no activity on LAP2/3.
ASP6432 inhibits LPA-induced urethra and prostate contractions in isolated rat tissue strips and anesthetized rats, decreases the urethral perfusion pressure (UPP) anesthetized rats.
| M.Wt | 598.774 | |
| Formula | C26H31KN4O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sakamoto K, et al. J Pharmacol Exp Ther. 2018 Jun 8. pii: jpet.118.247908.
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