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ASP8302

Chemical Structure : ASP8302

CAS No.: 1839583-42-4

ASP8302 (ASP-8302, ASP 8302)

Catalog No.: PC-72280Not For Human Use, Lab Use Only.

ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor.
Threonine 230 (Thr 230) is the amino acid essential for the PAM effect of ASP8302.

Physicochemical Properties

M.Wt 590.158
Formula C26H32ClN7O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[(2S)-4-(5-{[4-(4-chlorothiophen-2-yl)-5-{[(2R)-2-methylpyrrolidin-1-yl]methyl}-1,3-thiazol-2-yl]carbamoyl}pyrazin-2-yl)-2-methylpiperazin-1-yl]propanoic acid

References

1. Okimoto R, et al. J Pharmacol Exp Ther. 2021 Oct;379(1):64-73.

2. Okimoto R, et al. Low Urin Tract Symptoms. 2022 Feb 12.

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