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Chemical Structure : ASP9853
CAS No.: 442198-67-6
Catalog No.: PC-60993Not For Human Use, Lab Use Only.
ASP9853 is a potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ASP9853 is a potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS.
ASP9853 reduces NOx production in plasma from rats exposed to LPS (IC50=1.6 mg/kg), without effect on mean arterial blood pressure.
ASP9853 also shows greater tumor growth inhibition than docetaxel alone against non-small lung cancer xenografts in combination with docetaxe.
| M.Wt | 617.026 | |
| Formula | C29H28ClF3N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,E)-3-(4-chlorophenyl)-N-(1-oxo-1-((2-oxo-2-(4-((6-(trifluoromethyl)pyrimidin-4-yl)oxy)piperidin-1-yl)ethyl)amino)-3-(pyridin-2-yl)propan-2-yl)acrylamide |
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1. Luke JJ, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):549-58.
2. Chida N, et al. Eur J Pharmacol. 2005 Feb 10;509(1):71-6.
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