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Chemical Structure : AT-130
CAS No.: 211364-06-6
Catalog No.: PC-63327Not For Human Use, Lab Use Only.
AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | $758 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM.
AT-130 inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis.
AT-130 shows activity against the main lamivudine- and adefovir-resistant mutants.
| M.Wt | 488.338 | |
| Formula | C22H22BrN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N-(1-bromo-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)-4-nitrobenzamide |
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1. Delaney WE 4th, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60.
2. Feld JJ, et al. Antiviral Res. 2007 Nov;76(2):168-77.
3. Billioud G, et al. Antiviral Res. 2011 Nov;92(2):271-6.
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