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Chemical Structure : AT7867 dihydrochloride
CAS No.: 1431697-86-7
Catalog No.: PC-42874Not For Human Use, Lab Use Only.
AT7867 dihydrochloride is a potent, ATP-competitive, orally available dual Akt and p70S6K inhibitor with Ki of 17-85 nM, also inhibits PKA with Ki of 20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AT7867 dihydrochloride is a potent, ATP-competitive, orally available dual Akt and p70S6K inhibitor with Ki of 17-85 nM, also inhibits PKA with Ki of 20 nM.
AT7867 potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta (IC50=7.1 uM, pSer9 GSK3β in U87MG glioblastoma cells) and S6 ribosomal protein phosphorylation, causes growth inhibition in a range of human cancer cell lines.
AT7867 inhibits AKT and p70S6K and induces apoptosis, inhibits human tumor growth in PTEN-deficient xenograft models.
| M.Wt | 410.7678 | |
| Formula | C20H22Cl3N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-, hydrochloride (1:2) |
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1. Grimshaw KM, et al. Mol Cancer Ther. 2010 May;9(5):1100-10.
2. Zhang Q, et al. Oncotarget. 2016 Jul 19;7(29):46127-46141.
3. Zhang S, et al. PLoS One. 2017 Jan 12;12(1):e0169585.
4. Kimura A, et al. Stem Cell Res. 2017 Oct;24:61-68.
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