ATG4B activator 16a

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Chemical Structure : ATG4B activator 16a

Catalog No.: PC-26066Not For Human Use, Lab Use Only.

ATG4B activator 16a is a selective, allosteric small-molecule activator ATG4B, directly bind to the ATG4B with SPR KD of 0.22 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ATG4B activator 16a is a selective, allosteric small-molecule activator ATG4B, directly bind to the ATG4B with SPR KD of 0.22 uM.
ATG4B activator 16a can effectively inhibit the proliferation and migration of TNBC cells by suppressing MMP-2 mediated extracellular matrix degradation and reversing the EMT process.
ATG4B activator 16a induces autophagy to inhibit proliferation and migration in TNBC cells.
ATG4B activator 16a (5-20 mg/kg) induces autophagy to inhibit tumor growth and migration in the MDA-MB-231 xenograft model.

Physicochemical Properties

M.Wt	436.91
Formula	C25H22ClFN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((2-Chloro-4-fluorobenzyl)oxy)-3-methoxybenzyl)-1-(quinolin-8-yl)methanamine

References

1. Jin W, et al. Eur J Med Chem. 2026 Feb 17;308:118686.

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