Chemical Structure : ATH686
Catalog No.: PC-35271Not For Human Use, Lab Use Only.
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ATH686 (ATH-686) is a potent and selective, second-generation inhibitor of mutant FLT3 protein kinase; selectively kills leukemic cells harboring mutant FLT3 with no apparent effect on cells harboring wild-type FLT3, via inhibition of FLT3 kinase activity; potently inhibits cell proliferation of FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells (IC50<1 nM), via induction of apoptosis.
M.Wt | 515.541 | |
Formula | C25H28F3N7O2 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Weisberg E, et al. Genes Cancer. 2010 Oct;1(10):1021-32.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright