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Chemical Structure : ATI-2173
Catalog No.: PC-38561Not For Human Use, Lab Use Only.
ATI-2173 is a novel liver-targeted prodrug of clevudine, ATI-2173 is a selective inhibitor of HBV with EC50 of 1.31 nM in primary human hepatocytes with minimal to no toxicity.
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ATI-2173 is a novel liver-targeted prodrug of clevudine, ATI-2173 is a selective inhibitor of HBV with EC50 of 1.31 nM in primary human hepatocytes with minimal to no toxicity.
ATI-2173 is converted to the active 5′-triphosphate in hepatocytes.
ATI-2173 showed similar activity across HBV genotypes A, B, C, D, E, F, G, and H (EC50 of 212 nM to 718 nM) in HepG2 assays.
ATI-2173 activity was decreased by viral polymerase mutations associated with entecavir, lamivudine, and adefovir resistance, but not capsid inhibitor resistance mutations.
ATI-2173 demonstrated 82% hepatic extraction, no food effect, and greatly reduced peripheral exposure of clevudine compared with equimolar oral dosing of clevudine.
| M.Wt | 529.458 | |
| Formula | C22H29FN3O9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Squires KE, et al. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20.
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