Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ATI-2307
Catalog No.: PC-21197Not For Human Use, Lab Use Only.
ATI-2307 (T-2307) is a pentamidine-like compound with antifungal activity, selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ATI-2307 (T-2307) is a pentamidine-like compound with antifungal activity, selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells.
ATI-2307 shows a broad spectrum of activity against many fungal pathogens including Candida spp, Aspergillus spp., and C. neoformans.
ATI-2307 shows IC50 of 0.01-0.06 ug/mL against C. neoformans clinical isolates from Uganda.
ATI-2307 demonstrates significant fungicidal activity at dosages between 1 and 2 mg/kg/d, and is superior to fluconazole and similar to amphotericin B treatment in rabbit model cryptococcal meningoencephalitis (CM).
ATI-2307 disrupts the mitochondrial membrane potential and inhibits the respiratory chain complexes of fungi-it thus represents a new mechanism for direct antifungal action.
| M.Wt | 437.59 | |
| Formula | C25H35N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Gerlach ES, et al. Front Cell Infect Microbiol. 2021 Jun 23;11:695240.
2. Giamberardino CD, et al. Antimicrob Agents Chemother. 2023 Sep 20:e0081823.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
