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AVI-4516

Chemical Structure : AVI-4516

CAS No.:

AVI-4516

Catalog No.: PC-24476Not For Human Use, Lab Use Only.

AVI-4516 is a potent, selective, covalent SARS-CoV-2 main protease (MPro) inhibitor with IC50 of 29 nM, demonstrates potent in vivo antiviral efficacy.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AVI-4516 is a potent, selective, covalent SARS-CoV-2 main protease (MPro) inhibitor with IC50 of 29 nM, demonstrates potent in vivo antiviral efficacy.

Physicochemical Properties

M.Wt 408.42
Formula C23H16N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(1H-benzo[d][1,2,3]triazol-1-yl)-3-(isoquinolin-4-yl)-6-methyl-1-(prop-2-yn-1-yl)pyrimidine-2,4(1H,3H)-dione

References

1. Detomasi TC, et al. Sci Adv. 2025 Apr 25;11(17):eadt7836.

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