AVI-4773

Chemical Structure : AVI-4773

Catalog No.: PC-24475Not For Human Use, Lab Use Only.

AVI-4773 is a potent, selective, covalent SARS-CoV-2 main protease (MPro) inhibitor with IC50 of 38 nM, demonstrates potent in vivo antiviral efficacy.

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Biological Activity

AVI-4773 is a potent, selective, covalent SARS-CoV-2 main protease (MPro) inhibitor with IC50 of 38 nM, demonstrates potent in vivo antiviral efficacy.

Physicochemical Properties

M.Wt	444.40
Formula	C23H14F2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5,6-difluoro-1H-benzo[d][1,2,3]triazol-1-yl)-3-(isoquinolin-4-yl)-6-methyl-1-(prop-2-yn-1-yl)pyrimidine-2,4(1H,3H)-dione

References

1. Detomasi TC, et al. Sci Adv. 2025 Apr 25;11(17):eadt7836.

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AVI-4773

Biological Activity

Physicochemical Properties

References

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