AX-15836 |CAS:2035509-96-5 Probechem Biochemicals

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Chemical Structure : AX-15836

CAS No.: 2035509-96-5

AX-15836 (AX15836)

Catalog No.: PC-70300Not For Human Use, Lab Use Only.

AX-15836 (AX15836) is a potent, highly selective ERK5 inhibitor with IC50 of 8 nM.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$358	In stock
50 mg	$528	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AX-15836 (AX15836) is a potent, highly selective ERK5 inhibitor with IC50 of 8 nM.
AX-15836 shows little affinity for BRD4 (Kd=3.6 uM).
AX-15836 clearly inhibits the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells.

Physicochemical Properties

M.Wt	648.783
Formula	C32H40N8O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-11-(methylsulfonyl)-

References

1. Lin EC, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870.

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AX-15836 (AX15836)

Biological Activity

Physicochemical Properties

References

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