AX-35 | QcrB inhibitor, Cyt bc1 inhibitor

Chemical Structure : AX-35

AX-35 (GW861072X)

Catalog No.: PC-28676Not For Human Use, Lab Use Only.

AX-35 (GW861072X) is a potent M. tuberculosis inhibitor targeting the QcrB subunit of the cytochrome bc1 oxidase, has MIC of 0.05 ug/ml against M. tuberculosis H37Rv and 0.1 ug/mL for M. tuberculosis H37Rv-infected THP-1 macrophages.

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Biological Activity

Physicochemical Properties

M.Wt	356.44
Formula	C19H20N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one

References

1. Foo CS, et al. mBio. 2018 Oct 9;9(5):e01276-18.

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AX-35 (GW861072X)

Biological Activity

Physicochemical Properties

References

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