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Chemical Structure : AZ12216052
Catalog No.: PC-22232Not For Human Use, Lab Use Only.
AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays.
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AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays.
AZ12216052 shows no effect in GTPγS binding assays using membranes prepared from mGluR4-expressing GHEK cells.
The positive allosteric modulator effects of AZ12216052 were inhibited by the group-II/III antagonists LY341495 and CPPG.
| M.Wt | 392.36 | |
| Formula | C19H22BrNOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Duvoisin RM, et al. Behav Brain Res. 2010 Oct 15;212(2):168-73.
2. Reed BT, et al. Neuropharmacology. 2013 Apr;67:88-94.
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