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Chemical Structure : AZ6102
CAS No.: 1645286-75-4
Catalog No.: PC-43304Not For Human Use, Lab Use Only.
AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | Get quote |
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AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6).
AZ6102 potently inhibits Wnt pathway in DLD-1 cells with IC50 of 5 nM.
AZ6102 AZ6102 is a probe compound to explore the in vivo effects of TNKS1/2 inhibition on normal tissue and tumor xenografts.
| M.Wt | 428.5294 | |
| Formula | C25H28N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-,rel- |
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1. Johannes JW, et al. ACS Med Chem Lett. 2015 Jan 13;6(3):254-9.
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