Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AZ9482
CAS No.: 1825345-33-2
Catalog No.: PC-62699Not For Human Use, Lab Use Only.
AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 25 mg | $358 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively.
AZ9482 blocks centrosome clustering in HeLa cell with IC50 of <18 nM, shows activity in a Wnt pathway reporter assay, producing a DLD-1 firefly luciferase IC50 of 222 nM.
AZ9482 has been utilized as in vitro tool and in vivo probe to investigate the bio- logical consequences of inhibiting centrosome clustering through PARP enzymes.
| M.Wt | 450.502 | |
| Formula | C26H22N6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-(3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile |
|
1. Johannes JW, et al. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
