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AZD-0284

Chemical Structure : AZD-0284

CAS No.: 2101291-07-8

AZD-0284 (AZD0284)

Catalog No.: PC-63337Not For Human Use, Lab Use Only.

AZD-0284 is a potent, selective, orally bioavailable RORC2 inverse agonist with IC50 of 17 nM in TH17 cell assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-0284 is a potent, selective, orally bioavailable RORC2 inverse agonist with IC50 of 17 nM in TH17 cell assays.
AZD-0284 potently inhibited IL-17A secretion from primary human TH17 cells with excellent metabolic stability and good PK in preclinical species.
AZD-0284 reduced thymocyte numbers in mice and showed dose-dependent reduction of IL-17A containing γδ-T cells and of IL-17A and IL-22 RNA in the imiquimod induced inflammation model. 

Physicochemical Properties

M.Wt 524.434
Formula C21H18F6N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide

References

1. Frank Narjes, et al. J Med Chem. 2021 Sep 23;64(18):13807-13829.

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