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Chemical Structure : AZD-0865
CAS No.: 248919-64-4
Catalog No.: PC-42143Not For Human Use, Lab Use Only.
A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
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A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5; inhibits H+/K+-ATPase activity in a K(+)-competitive manner with Ki of 46 nM, shows no ativity for porcine renal Na(+),K(+)-ATPase at 100 uM; inhibits gastric acid secretion in vivo.
Ulcer
Phase 2 Discontinued
| M.Wt | 366.4567 | |
| Formula | C21H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl- |
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1. Bailey N, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6.
2. Gedda K, et al. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.
3. Kirchhoff P, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G838-43.
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